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The 2022–2023 United States Pseudomonas aeruginosa outbreak began in May 2022, with the infection of several patients in California. The Centers for Disease Control and Prevention (CDC) became aware of a strain of Pseudomonas aeruginosa in artificial tears manufactured by EzriCare and Delsam Pharma in January 2023.
While definitive sites of metabolism have not been firmly established, there are several metabolites worthy of note. N-Desethylbrinzolamide is an active metabolite of the parent compound, and thus exhibits carbonic anhydrase inhibitory activity (largely carbonic anhydrase-I, when in the presence of Brinzolamide) and also accumulates in the erythrocytes.
Rimexolone is a glucocorticoid steroid used to treat inflammation in the eye. [1] It is marketed as a 1% eye drop suspension under the trade name Vexol by Alcon Laboratories, but was discontinued in the US and other countries. [2] [3]
Eye drops or eyedrops are liquid drops applied directly to the surface of the eye usually in small amounts such as a single drop or a few drops. Eye drops usually contain saline to match the salinity of the eye. Drops containing only saline and sometimes a lubricant are often used as artificial tears to treat dry eyes or simple eye irritation ...
Ciprodex, owned by Alcon Laboratories, Inc., is protected by multiple patents and will be restricted from generic manufacturing until 2025. [6] [7] Ciprodex is the number 1 topical antibiotic ear drop prescribed since 2007 by ENTs and pediatricians.
Nepafenac, sold under the brand name Nevanac among others, is a nonsteroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop 0.1% solution (Nevanac) or 0.3% solution (Ilevro). It is used to treat pain and inflammation associated with cataract surgery. [ 3 ]
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