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Clark International Airport ( IATA: CRK, ICAO: RPLC ), known as Diosdado Macapagal International Airport from 2003 to 2014, is an international airport covering portions of the cities of Angeles and Mabalacat within the Clark Freeport Zone in the province of Pampanga, Philippines. It is located 80 kilometers (50 mi) [6] northwest of Manila.
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Active (GTP-bound) RhoG recruits the ELMO/Dock180 complex to the plasma membrane thereby bringing Dock180 into contact with its substrate, Rac. In tumour cells DOCK180 is regulated by a complex containing Crk and p130Cas which is in turn regulated by cooperative signalling by β 3 -containing integrin complexes and the membrane-bound protein uPAR .
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