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Arizona (/ ˌ ær ɪ ˈ z oʊ n ə / ⓘ ARR-iz-OH-nə; Navajo: Hoozdo Hahoodzo [hoː˥z̥to˩ ha˩hoː˩tso˩]; [10] O'odham: Alĭ ṣonak [ˈaɭi̥ ˈʂɔnak]) [11] is a state in the Southwestern region of the United States, sharing the Four Corners region of the western United States with Colorado, New Mexico, and Utah.
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The intravenous dose causing 50% of opioid-naive experimental subjects to die (LD 50) is "3 mg/kg in rats, 1 mg/kg in cats, 14 mg/kg in dogs, and 0.03 mg/kg in monkeys." [ 96 ] The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. [ 97 ]
Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4][8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9]
Ronald Wilson Reagan [a] (February 6, 1911 – June 5, 2004) was an American politician and actor who served as the 40th president of the United States from 1981 to 1989. A member of the Republican Party, his presidency constituted the Reagan era, and he is considered one of the most prominent American conservative figures.